Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

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Pathology of Xanthogranulomatous Cholecystitis.

Dr Sampurna Roy MD. Xanthogranulomatous cholecystitis is a destructive inflammatory disease of the gallbladder, rarely involving adjacent organs and mimicking an advanced gallbladder carcinoma.

The lesions appear to result from ruptured Rokitansky-Aschoff sinuses with intramural extravasation of bile and subsequent xanthogranulomatous reaction.

It has been suggested that xanthogranulomatous cholecystitis can be divided into two forms: The diagnosis is usually possible only after pathological examination. Gallstones are present in most cases. This unusual entity is characterized morphologically by a broad spectrum of xanthogranulomatous changes seen from a small limited focus within yellow nodule in the gallbladder wall, to diffuse involvement of the entire gallbladder with extension of the fibrosis into surrounding tissues.


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Xanthogranulomatous cholecystitis may form a tumour-like mass in inflamed gallbladders. Grossly the lesions are usually soft, yellow to brown, and measure up to 2. Lipid is ingested by macrophages, which have the appearance of xanthoma cells and giant cells of foreign- body and Touton type.

This is usually seen in association with dense fibrous tissue. At operation, there are adhesions to surrounding tissues, and sometimes a mass is found, mimicking tumour of the gallbladder.

Acute cholecystitis ; Acalculous cholecystitis ; Emphysematous cholecystitis ; Eosinophilic Xanthogranulomatoue ; Necrobiotic Xanthogranuloma of the the skin. Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature. Epidemiology of xanthogranulomatous cholecystitis. Xanthogranulomatous cholecystitis in laparoscopic surgery.

Surgical procedures and histopathologic findings for patients with xanthogranulomatous cholecystitis.: J Am Xantyogranulomatous Surg. Retrospective analysis of 12 cases.

Pathology Outlines – Xanthogranulomatous cholecystitis

Genetic analysis of xanthogranulomatous cholecystitis: Histopathological study and xahthogranulomatous. Surgical treatment of xanthogranulomatous cholecystitis: Hepatobiliary Pancreat Dis Int. Perfidious gallbladders – a diagnostic dilemma with xanthogranulomatous cholecystitis. Ann R Coll Surg Engl.


Cytopathologic diagnosis of xanthogranulomatous cholecystitis and coexistent lesions.

A Case of Xanthogranulomatous Cholecystitis

A prospective study of 31 cases. Xanthogranulomatous cholecystitis mimicking gallbladder cancer: Infectious etiology of xanthogranulomatous cholecystitis: Cell composition and a possible pathogenetic role of cell-mediated immunity. Preoperative diagnosis of xanthogranulomatous cholecystitis. A clinicopathological study of 20 cases and review of the literature.

Clinico-pathological study of xanthogranulomatous cholecystitis. Nippon Geka Gakkai Zasshi. A clinical and pathologic study of twelve cases.

Xanthogranulomatous cholecystitis. Histopathological study and classification.

Xanthogranulomatous cholecystitis mimicking stage IV gallbladder cancer. Soft Tissue Tumour Online. Microscope – Seeing the Unseen.