Index Terms: Asymptomatic, canine distemper, diagnosis, dogs. Amostra vacinal do vírus da cinomose canina em células VERO foi utilizada como controle. Canine distemper virus infection and secondary Bordetella bronchiseptica Palavras-chave: cães, vírus da cinomose canina, Bordetella bronchiseptica.

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Canine distemper

Canine distemper virus infection and secondary Bordetella bronchiseptica pneumonia are described in mongrel dogs. Canine distemper was characterised by nonsuppurative demyelinating encephalitis with typical inclusion bodies in astrocytes.

Neurologic manifestations are generally fatal, and may be responsible for the high morbidity and mortality in dogs unvaccinated or inadequately vaccinated APPLE, This report describes the gross and microscopic findings of CDV infection associated with secondary bacterial pneumonia induced by Bordetella bronchiseptica dstemper two dogs submitted for routine necropsy. Dog number one, a male of 18 months of age, was unvaccinated, had progressive weight loss, purulent ocular discharge, corneal opacity of the left eye, persistent cough, and died suddenly.

Dog number two, a five-month old female, was vaccinated at three months of age, developed a chronic cough of about thirty days duration, during which purulent ocular and nasal discharges were observed.

Canine distemper – Wikipedia

The referring veterinarian administered benzetacil for seven days, followed by gentamycin during another ten days. However, no pulmonary relief was obtained, and a switch was made to trimethoprim and sulphadiazine, also without any further success. Pulmonary distress worsened and euthanasia was realised. Both dogs were necropsied shortly after death.


Both were in good body condition and had purulent ocular secretion, but abdominal pustules were present only in dog number two. Specimens of infected pulmonary tissue were collected asseptically and sent for bacterial evaluation. Nervous tissues were unaltered at necropsy.

However, microscopic examination revealed non-suppurative demyelinating encephalitis in both cases. Various areas of demyelination with eosinophilic intranuclear inclusion bodies characteristic of CDV, principally in astrocytes, were observed ditsemper the cerebellum.

Associated to these areas of white caninna demyelination were perivascular cuffs, formed by two to three layers of mononuclear cells and lymphocytes, discrete gliosis, and moderate astrogliosis. Gross pulmonary alterations were similar with little individual variation. The pleura was smooth and glistening.

Canine distemper virus detection in asymptomatic and non vaccinated dogs

Areas of consolidation, and other large irregular shaped, greenish-grey, slightly depressed areas were seen, principally at the border of some pulmonary lobes.

Pulmonary sections revealed multiple, different sized, pus-filled areas, with marked accumulation of oedematous ditemper within the tracheal air space. Histopathological evaluation revealed severe purulent broncopneumonia.

In these cases, marked accumulation of distemped neutrophils in bronchial and alveolar air spaces, necrosis of bronchiolar and bronchial epithelial cells, small isolated foci of severe necrosis, scattered haemorrhagic areas, and intralesional bacteria were observed. Pulmonary specimens revealed pure cultures of Bordetella bronchiseptica.


Other significant gross lesions were ddistemper and enlarged regional lymph nodes of dog two, which corresponded to severe cortical haemorrhage with moderate depletion of lymphatic tissues and absence of cortical-medular differentiation microscopically.

Distemper Canino

Dog number two presented abdominal pustules, which are thought to be the result of streptococci and staphylococci bacterial complications and normally considered as cutaneous manifestation of CDV infection DUNGWORTH, Therefore, caution should be taken by veterinary practitioners when treating bacterial infections in which distemper, other encephalitides, or infectious agents are suspected as occurring concomitantly.

Additionally, vaccination programmes, aimed at distemper and other infectious canine diseases considered enzootic, should be adapted, and maintained in urban dog populations, in an attempt to combat such infections and reduce the chance of opportunistic bacterial or other infections. Universidad Nacional del Litoral, All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

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