Chandipura virus (CHPV), initially thought to be an orphan virus, was later reported to cause sporadic cases of fever with arthralgia, Reye’s syndrome, and. Chandipura virus (CHPV; genus Vesiculovirus, family Rhabdoviridae) is an emerging tropical pathogen with a case fatality rate of 55 to 75% that predominantly. Chandipura virus: A virus that causes fever, symptoms similar to those of flu, and acute encephalitis (inflammation of the brain). Chandipura virus was first.

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In AP also, the clinical progression of the disease was similar to that of the index case. These protein-protein interactions PPIs are achieved through specific regions that are responsible for the physical interactions.

Advances in Virology

CPE was distinct and characterized by rounding of cells followed by detachment and rapid deterioration. Open in a separate window.

Filoviridae Viral hemorrhagic fevers: The natural factors contributing towards the amplification of the virus leading to outbreaks are still not understood. Antivirals In the field of antivirals, siRNAs have been found to be promising as inhibition of virus replication was observed both in vitro and in vivo Vector control CHPV is transmitted by Phlebotomine sandflies as evidenced by repeated isolations and their ability to transmit the virus by transovarial and venereal routes 2324 Comparative studies on the infection of invertebrate and vertebrate cell lines with some arbovirusesPh.

Viruw Chattopadhyay of Dr.

J Med Entomol ; In this phase, same L protein acts as a replicase and ignore the gene junctions to generate a polycistronic anti-genomic analogue that acts as a template for further rounds of replication to generate many more copies of the genome RNA. During the life cycle of viruses, the encoded proteins extensively interact with one another to perform their functions. The significance of Chandipura virus as a human pathogen is unresolved due to doubts over its role in the and chandi;ura.


In majority of the cases, mortality was reported within 24 h of commencement of symptoms. Matrix protein glues the encapsidated genome RNA, also known as nucleocapsid, with the outer membrane envelop. The ribonucleoprotein complex gets bound to the M protein which further includes the host plasma membrane to form the lipid envelope.

First isolations of arboviruses from phlebotomine chandkpura flies in Chanripura Africa. Majority of the viruses in the genus are transmitted by Phlebotomine sandflies. Chandipura virus encephalitis outbreak among children in Virys division, Maharashtra, In order to investigate dhandipura interacting regions of N protein, a series of interaction studies employing bioinformatics-based docking studies, yeast two-hybrid system, and ELISA have been performed.

Prasad RS, Thomas C, editors. Cell death and endoplasmic reticulum stress: ROS effects on neurodegeneration in Alzheimer’s disease and related disorders: Rabies virus, the prototype virus of genus Lyssavirusis the most important pathogen of Rhabdoviridae with a worldwide distribution. Seroepidemiology of dengue and other arboviruses in a natural population of toque macaques Macaca sinica at Polonnaruwa, Sri Lanka.

Is Chandipura virus an emerging human pathogen?

Induction of stress granule-like structures chandipra vesicular stomatitis virus-infected cells. In a recent study, chandipurq authors had mapped the associations among CHPV proteins and shown that N protein interacts with four of the viral proteins: Endoplasmic Reticulum and Oxidative Stress: Antibody titres of individual components persisted for six months chabdipura significant drop. Interactions were considered in both directions, that is, as BD and AD fusions. CHIP transmission by sandflies Experimental studies with Phlebotomus papatasi showed their potential not only to replicate the virus but also to transmit the virus through vertical, venereal and horizontal routes 23 Significant contributions have been made in the development of diagnostics and prophylactics, vaccines and antivirals.


Chandipura virus induces neuronal death through Fas- mediated extrinsic apoptotic pathway.

Chandipura virus – Wikipedia

Two log reduction in virus titre was obtained in the siRNA treated Vero cells in comparison to controls. There have been no adverse consequences.

Rhabdoviridae from Sergentomyia species of sandflies frm Nagpur, Maharashtra, India. Spraying of insecticides could bring down the population drastically.

With the elucidation of interactions of N protein with M and G proteins [ 14 ], there arises a need to further map the specific regions of CHPV N protein involved in mediating its interactions.

The virus was subsequently isolated from Phlebotomine sandflies, the incriminated vector of CHPV, collected from Aurangabad district, Maharashtra, India, during Amongst the 10 genera, genus Lyssavirus and genus Vesiculovirus are of public health importance.

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