ABSTRACT: Chronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch . Candidal leukoplakia is usually considered to be a largely historical synonym for a type of oral candidiasis, now more. Clinically the lesions could not be reliably differentiated from “leukoplakia” due Recognition of chronic hyperplastic candidiasis from other “leukoplakias” is of.

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Photo of Candidal Leukoplakia of the R Commissure. What is Candidal Leukoplakia?

Chronic oral candidosis produces a tough, adherent, white plaque leukoplakiadistinguishable only by biopsy from other leukoplakias.

Candidal leukoplakia is an uncommon condition found in adults. What is the Cause of Candidal Leukoplakia? The cellular changes often include hyperplasia ; however, cellular changes can occur that range from mild dysplasia to invasive carcinoma.

Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia). – Semantic Scholar

The Candida biotypes associated with candidal leukoplakia differ from those isolated from normal mouths. Candidal leukoplakia may be predisposed to in a minority of patients by: What are the signs and symptoms?

Adults, typically males of middle age or over, are affected. The usual sites are the caniddal of the tongue and the post- commissural buccal mucosa see photos. Angular stomatitis may be associated, is sometimes continuous with intra-oral plaques and suggests the candidal nature of the lesion.


Candidal leukoplakias are chronic, discrete, raised lesions that vary from small, palpable, translucent, whitish areas to large, dense, opaque plaques, hard and rough to the touch plaque-like lesions. Homogeneous areas or speckled areas can be seen, which do not rub off nodular lesions.

Candidal leukoplakias leukooplakia occur on the buccal mucosa on one or both sides, mainly just inside the commissureless often on the tongue.


How Is It Diagnosed? Unlike Thrush weblinkthe plaque cannot be wiped off but fragments can be detached by firm scraping.

Electron microscopy shows Candida albicans to be an intra- cellular parasite growing within the epithelial cytoplasm. Induction of epithelial proliferation by C. Dysplasia definition may be present, especially in speckled lesions.

Candidal leukoplakia should be biopsied both to: How is it treated? After confirmation of the diagnosis by histology, treatment should be with a systemic anti-fungal drug such as fluconazole this may have to be continued for several months.

Other factors likely to perpetuate candidal infection should be controlled. Stopping the patient from smoking and elimination of candidal infection from under an upper denture are important. Any iron deficiency should also be treated. Excision of candidal plaque alone is of little value, as the infection can recur in the same site even after skin grafting.


Vigorous anti- fungal therapy is therefore essential but sometimes some residual uninfected plaque may persist after treatment and lesions often recur and require long-term intermittent anti-fungal therapy. Prognosis The potential for malignant change exists.

Factors influencing the prognosis may include: Tobacco and alcohol habits should be stopped. Anti-fungals should be used. The lesions of candidal leukoplakia may prove poorly responsive to polyene anti- fungal drugs such as and, in some cases, respond only to systemic fluconazole. Excision is indicated if there is more than mild dysplasia.

The patient should be fully informed about the condition and reviewed regularly. Postgrad Med J Last Updated 18th August