BATS ARE NATURAL RESERVOIRS OF SARS-LIKE CORONAVIRUSES PDF

Severe acute respiratory syndrome (SARS) was caused by a newly emerged coronavirus, now known as SARS coronavirus (SARS-CoV). (1, 2). In spite of the . PDF | Severe acute respiratory syndrome (SARS) emerged in to in southern China. The origin of its etiological agent, the SARS. Severe acute respiratory syndrome (SARS) emerged in to in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV).

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Bats are natural reservoirs of SARS-like coronaviruses.

Coronavirus link A decade after the SARS pandemic, scientists have found the strongest evidence to date it originated in bats. A team of mostly Chinese researchers report today in the journal Nature they have isolated two new viruses that are closely related to ade SARS virus.

Finding the natural “reservoir” of the SARS virus – a coronavirus – is an important part of being prepared for the future, says Crameri. SARS first broke out in “wet markets” in China, which involved the sale of live animals – often from the wild. While civet cats were first thought to be the reservoir, researchers soon discovered that these animals were only infected sard-like markets. He was involved in nafural number of studies that found genetic evidence that cave-dwelling microbats, sold as a food source in wet markets, were harbouring SARS-like coronaviruses.

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Bats May Be Animal Reservoir For SARS Virus | Medpage Today

But the viruses differed from SARS, particularly in the region of the virus that binds to a host protein called ACE2, facilitating infection, says Crameri. Since these SARS-like viruses do not bind to ACE2, this made researchers wonder whether SARS really came from bats, or whether it needed an intermediate host to convert the virus into a form that could infect humans.

Crameri and colleagues showed that cells from humans, mice and bats, which did not express ACE2, were not infected by the new viruses but once the cells were modified to express ACE2, the viruses did infect them. The researchers coronavituses found that the new viruses also had exactly the same proteins used by the SARS virus to bind to ACE2 in host cells.

They don’t need any intermediate hosts,” says Crameri.

He says this is also the first time researchers have been able to isolate a live coronavirus from bats. Prior to this, only fragments of coronavirus DNA had been found in bats.

Bats May Be Animal Reservoir For SARS Virus

Crameri says the MERS virus, which also appears to come from a microbat, binds to human cells via a different receptor and is less infectious than SARS, but kills a higher percentage of those it infects. Bats are an ancient animal that diverged from other mammals 80 million years ago and Crameri says this could explain why they carry a high number of pathogens that they themselves are unaffected by.

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Humans are mainly exposed to viruses from bats via the animals’ faeces, says Crameri, adding that stress in the animals appears to increase this shedding. Now that animals, including bats, and humans live closer together as our population expands globally, the opportunity for direct transmission of these dangerous viruses becomes more and more of an coronaaviruses.

Bats are natural reservoirs of SARS-like coronaviruses. – Semantic Scholar

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